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The Effect of MUC1 rs4072037 Functional Polymorphism on Cancer Susceptibility: Evidence from Published Studies

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  • Fujiao Duan
  • Chunhua Song
  • Liping Dai
  • Shuli Cui
  • Xiaoqin Zhang
  • Xia Zhao

Abstract

Genome-wide association studies have identified a susceptibility variation MUC1 rs4072037 for gastric cancer in Chinese population. Subsequent case-control studies have reported this association in other populations. However, the results remain controversial and ambiguous. The aim of this study is to provide a precise quantification for the association between MUC1 rs4072037 variation and the risk of cancer. We performed pooled analysis of 10 case-control designed studies including 4,220 cases and 6,384 controls. Odds ratios (OR) and 95% confidence interval (95%CI) were calculated to assess strength of association in overall studies and in subgroup analysis stratified by ethnicity and cancer types. All statistical analyses were performed by Manager 5.0 and Stata 12.0 software. Overall, the MUC1 rs4072037 polymorphism was associated with risk of cancer in all genetic models (G vs A: OR = 0.71, 95%CI: 0.63–0.80, p

Suggested Citation

  • Fujiao Duan & Chunhua Song & Liping Dai & Shuli Cui & Xiaoqin Zhang & Xia Zhao, 2014. "The Effect of MUC1 rs4072037 Functional Polymorphism on Cancer Susceptibility: Evidence from Published Studies," PLOS ONE, Public Library of Science, vol. 9(4), pages 1-7, April.
    • Handle: RePEc:plo:pone00:0095651
    DOI: 10.1371/journal.pone.0095651
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