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Carvedilol for Prevention of Atrial Fibrillation after Cardiac Surgery: A Meta-Analysis

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  • Hui-Shan Wang
  • Zeng-Wei Wang
  • Zong-Tao Yin

Abstract

Background: Postoperative atrial fibrillation (POAF) remains the most common complication after cardiac surgery. Current guidelines recommend β-blockers to prevent POAF. Carvedilol is a non-selective β-adrenergic blocker with anti-inflammatory, antioxidant, and multiple cationic channel blocking properties. These unique properties of carvedilol have generated interest in its use as a prophylaxis for POAF. Objective: To investigate the efficacy of carvedilol in preventing POAF. Methods: PubMed from the inception to September 2013 was searched for studies assessing the effect of carvedilol on POAF occurrence. Pooled relative risk (RR) with 95% confidence interval (CI) was calculated using random- or fixed-effect models when appropriate. Six comparative trials (three randomized controlled trials and three nonrandomized controlled trials) including 765 participants met the inclusion criteria. Results: Carvedilol was associated with a significant reduction in POAF (relative risk [RR] 0.49, 95% confidence interval [CI] 0.37 to 0.64, p

Suggested Citation

  • Hui-Shan Wang & Zeng-Wei Wang & Zong-Tao Yin, 2014. "Carvedilol for Prevention of Atrial Fibrillation after Cardiac Surgery: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(4), pages 1-7, April.
    • Handle: RePEc:plo:pone00:0094005
    DOI: 10.1371/journal.pone.0094005
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