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A Core Invasiveness Gene Signature Reflects Epithelial-to-Mesenchymal Transition but Not Metastatic Potential in Breast Cancer Cell Lines and Tissue Samples

Author

Listed:
  • Melike Marsan
  • Gert Van den Eynden
  • Ridha Limame
  • Patrick Neven
  • Jan Hauspy
  • Peter A Van Dam
  • Ignace Vergote
  • Luc Y Dirix
  • Peter B Vermeulen
  • Steven J Van Laere

Abstract

Introduction: Metastases remain the primary cause of cancer-related death. The acquisition of invasive tumour cell behaviour is thought to be a cornerstone of the metastatic cascade. Therefore, gene signatures related to invasiveness could aid in stratifying patients according to their prognostic profile. In the present study we aimed at identifying an invasiveness gene signature and investigated its biological relevance in breast cancer. Methods & Results: We collected a set of published gene signatures related to cell motility and invasion. Using this collection, we identified 16 genes that were represented at a higher frequency than observed by coincidence, hereafter named the core invasiveness gene signature. Principal component analysis showed that these overrepresented genes were able to segregate invasive and non-invasive breast cancer cell lines, outperforming sets of 16 randomly selected genes (all P

Suggested Citation

  • Melike Marsan & Gert Van den Eynden & Ridha Limame & Patrick Neven & Jan Hauspy & Peter A Van Dam & Ignace Vergote & Luc Y Dirix & Peter B Vermeulen & Steven J Van Laere, 2014. "A Core Invasiveness Gene Signature Reflects Epithelial-to-Mesenchymal Transition but Not Metastatic Potential in Breast Cancer Cell Lines and Tissue Samples," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-13, February.
    • Handle: RePEc:plo:pone00:0089262
    DOI: 10.1371/journal.pone.0089262
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