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How Often Should We Monitor for Reliable Detection of Atrial Fibrillation Recurrence? Efficiency Considerations and Implications for Study Design

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  • Efstratios I Charitos
  • Paul D Ziegler
  • Ulrich Stierle
  • Derek R Robinson
  • Bernhard Graf
  • Hans-Hinrich Sievers
  • Thorsten Hanke

Abstract

Objective: Although atrial fibrillation (AF) recurrence is unpredictable in terms of onset and duration, current intermittent rhythm monitoring (IRM) diagnostic modalities are short-termed and discontinuous. The aim of the present study was to investigate the necessary IRM frequency required to reliably detect recurrence of various AF recurrence patterns. Methods: The rhythm histories of 647 patients (mean AF burden: 12±22% of monitored time; 687 patient-years) with implantable continuous monitoring devices were reconstructed and analyzed. With the use of computationally intensive simulation, we evaluated the necessary IRM frequency to reliably detect AF recurrence of various AF phenotypes using IRM of various durations. Results: The IRM frequency required for reliable AF detection depends on the amount and temporal aggregation of the AF recurrence (p 95% sensitivity) of AF recurrence required higher IRM frequencies (>12 24-hour; >6 7-day; >4 14-day; >3 30-day IRM per year; p

Suggested Citation

  • Efstratios I Charitos & Paul D Ziegler & Ulrich Stierle & Derek R Robinson & Bernhard Graf & Hans-Hinrich Sievers & Thorsten Hanke, 2014. "How Often Should We Monitor for Reliable Detection of Atrial Fibrillation Recurrence? Efficiency Considerations and Implications for Study Design," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-11, February.
    • Handle: RePEc:plo:pone00:0089022
    DOI: 10.1371/journal.pone.0089022
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    Cited by:

    1. Jakob Schroder & Olivier Bouaziz & Bue Ross Agner & Torben Martinussen & Per Lav Madsen & Dana Li & Ulrik Dixen, 2019. "Recurrent event survival analysis predicts future risk of hospitalization in patients with paroxysmal and persistent atrial fibrillation," PLOS ONE, Public Library of Science, vol. 14(6), pages 1-12, June.

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