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Association between Fat Mass- and Obesity- Associated (FTO) Gene Polymorphism and Polycystic Ovary Syndrome: A Meta-Analysis

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  • Xianli Cai
  • Chibo Liu
  • Sihua Mou

Abstract

Aims: Many studies have investigated the relationship between FTO gene polymorphism and polycystic ovary syndrome (PCOS) susceptibility but revealed mixed results. In this study, we aimed to perform a meta-analysis to clarify this association. Methods: Published literature from PubMed, Embase and CNKI was retrieved. Meta-analysis was performed to calculate pooled odds ratio (OR) with 95% confidence interval (CI) using the random- or fix- effects model. Results: A total of 5 studies (4778 cases and 4272 controls) were included in our meta-analysis. The results suggested that FTO rs9939609 polymorphism (or its proxy) was marginally associated with PCOS risk after adjustment for body mass index (BMI) (OR = 1.26; 95%CI: 1.02–1.55). However, the marginal association was not stable after sensitivity analysis. In the subgroup analysis by ethnicity, the association was significant in East Asians (OR = 1.43, 95%CI = 1.30–1.59) but not in Caucasians (OR = 1.04, 95%CI = 0.85–1.29). Conclusions: Our present meta-analysis indicated that FTO rs9939609 polymorphism (or its proxy) might not be associated with risk of PCOS in overall population. However, in East Asians, there might be a direct association between FTO variant and PCOS risk, which is independent of BMI (adiposity).

Suggested Citation

  • Xianli Cai & Chibo Liu & Sihua Mou, 2014. "Association between Fat Mass- and Obesity- Associated (FTO) Gene Polymorphism and Polycystic Ovary Syndrome: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-5, January.
    • Handle: RePEc:plo:pone00:0086972
    DOI: 10.1371/journal.pone.0086972
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    1. Tao Li & Keliang Wu & Li You & Xiuye Xing & Peng Wang & Linlin Cui & Hongbin Liu & Yuqian Cui & Yuehong Bian & Yunna Ning & Han Zhao & Rong Tang & Zi-Jiang Chen, 2013. "Common Variant rs9939609 in Gene FTO Confers Risk to Polycystic Ovary Syndrome," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-6, July.
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