Author
Listed:
- Jeewook Choi
- Bumseok Jeong
- Sang Won Lee
- Hyo-Jin Go
Abstract
Objective: The aim of this study was to investigate the compromised developmental trajectory of the functional connectivity among resting-state-related functional networks (RSFNs) in medication-naïve children with attention-deficit/hyperactivity disorder (ADHD). Subjects and Methods: Using both independent component analysis and dual regression, subject-specific time courses of 12 RSFNs were extracted from both 20 medication-naïve children with ADHD, and 20 age and gender-matched control children showing typical development (TDC). Both partial correlation coefficients among the 12 RSFNs and a resting-state resource allocation index (rsRAI) of the salience network (SN) were entered into multiple linear regression analysis to investigate the compromised, age-related change in medication-naïve ADHD children. Finally, correlation analyses were performed between the compromised RSFN connections showing significant group-by-age interaction and rsRAI of SN or clinical variables. Results: Medication-naïve ADHD subjects failed to show age-related increment of functional connectivity in both rsRAI of SN and two RSFN connections, SN-Sensory/motor and posterior default mode/precuneus network (pDMN/prec) – anterior DMN. Lower SN-Sensory/motor connectivity was related with higher scores on the ADHD Rating Scale, and with poor scores on the continuous performance test. The pDMN/prec-aDMN connectivity was positively related with rsRAI of SN. Conclusions: Our results suggest that medication-naïve ADHD subjects may have delayed maturation of the two functional connections, SN-Sensory/Motor and aDMN-pDMN/prec. Interventions that enhance the functional connectivity of these two connections may merit attention as potential therapeutic or preventive options in both ADHD and TDC.
Suggested Citation
Jeewook Choi & Bumseok Jeong & Sang Won Lee & Hyo-Jin Go, 2013.
"Aberrant Development of Functional Connectivity among Resting State-Related Functional Networks in Medication-Naïve ADHD Children,"
PLOS ONE, Public Library of Science, vol. 8(12), pages 1-11, December.
Handle:
RePEc:plo:pone00:0083516
DOI: 10.1371/journal.pone.0083516
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