IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0083422.html
   My bibliography  Save this article

A Genetic Association Study of CCL5 -28 C>G (rs2280788) Polymorphism with Risk of Tuberculosis: A Meta-Analysis

Author

Listed:
  • Mohammed A A Alqumber
  • Raju K Mandal
  • Shafiul Haque
  • Aditya K Panda
  • Naseem Akhter
  • Arif Ali

Abstract

Aim: The CC chemokine ligand 5 (CCL5), plays a key role in the inflammatory response by recruiting mononuclear cells during tuberculosis (TB) infection. Association studies of CCL5 -28 C>G (rs2280788) polymorphism and TB risk have shown inconsistent and contradictory results among different ethnic populations. The aim of this meta-analysis is to investigate the association between CCL5 -28 C>G polymorphism and TB susceptibility. Methodology: We performed quantitative synthesis for published studies based upon association between CCL5 -28 C>G polymorphism and TB risk from PubMed (Medline), EMBASE web databases. The meta-analysis was performed and pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for all genetic models. Results: A total of six studies including 1324 TB cases and 1407 controls were involved in this meta-analysis. Variant allele (G vs. C: p = 0.257; OR = 1.809, 95% CI = 0.649 to 5.043), heterozygous (CG vs. CC: p = 0.443; OR = 1.440, 95% CI = 0.567 to 3.658) and homozygous (GG vs. CC: p = 0.160; OR = 5.140, 95% CI = 0.524 to 50.404) carriers did not show increased risk compare with those individual with the CC genotype. Similarly, no associations were found in the dominant (GG+CG vs. CC: p = 0.295; OR = 1.802, 95% CI = 0.599 to 5.412) and recessive (GG vs. CC+CG: p = 0.188; OR = 3.533, 95% CI = 0.541 to 23.085) models. Conclusions: Overall findings of this meta-analysis suggest that genetic polymorphism -28 C>G in CCL5 is not associated with increased TB risk. However, future larger studies with group of populations will be needed to analyze the relationship between the CCL5 -28 C>G polymorphism and risk of TB.

Suggested Citation

  • Mohammed A A Alqumber & Raju K Mandal & Shafiul Haque & Aditya K Panda & Naseem Akhter & Arif Ali, 2013. "A Genetic Association Study of CCL5 -28 C>G (rs2280788) Polymorphism with Risk of Tuberculosis: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-6, December.
    • Handle: RePEc:plo:pone00:0083422
    DOI: 10.1371/journal.pone.0083422
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083422
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0083422&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0083422?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. MY Areeshi & Raju K Mandal & Aditya K Panda & Shekhar C Bisht & Shafiul Haque, 2013. "CD14 −159 C>T Gene Polymorphism with Increased Risk of Tuberculosis: Evidence from a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-6, May.
    2. Wu Rongling & Bailian Li, 1999. "A Multiplicative-Epistatic Model for Analyzing Interspecific Differences in Outcrossing Species," Biometrics, The International Biometric Society, vol. 55(2), pages 355-365, June.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Peiliang Geng & Jianjun Li & Ning Wang & Juanjuan Ou & Ganfeng Xie & Chen Liu & Xiaoxin Zhao & Lisha Xiang & Yunmei Liao & Houjie Liang, 2015. "PSCA rs2294008 Polymorphism with Increased Risk of Cancer," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-12, August.
    2. Mohammed A A Alqumber & Naseem Akhter & Shafiul Haque & Aditya K Panda & Raju K Mandal, 2014. "Evaluating the Association between p53 Codon 72 Arg>Pro Polymorphism and Risk of Ovary Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(4), pages 1-7, April.
    3. Raju K Mandal & Naseem Akhter & Shafiul Haque & Aditya K Panda & Rama D Mittal & Mohammed A A Alqumber, 2014. "No Correlation between TIMP2 -418 G>C Polymorphism and Increased Risk of Cancer: Evidence from a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(8), pages 1-7, August.
    4. M Y Areeshi & Raju K Mandal & Aditya K Panda & Shafiul Haque, 2013. "A Meta-Analysis of the Association between the CC Chemokine Ligand 5 (CCL5) -403 G>A Gene Polymorphism and Tuberculosis Susceptibility," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-6, August.
    5. Mohammed Y Areeshi & Shafiul Haque & Aditya K Panda & Raju K Mandal, 2013. "A Serotonin Transporter Gene (SLC6A4) Polymorphism Is Associated with Reduced Risk of Irritable Bowel Syndrome in American and Asian Population: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-1, September.
    6. Yiqiong Zhao & Dong Fu & Kai Chen & Guodong Li & Zhengdong Cai & Yan Shi & Xiaobing Yin, 2014. "Outcome of Hemiarthroplasty and Total Hip Replacement for Active Elderly Patients with Displaced Femoral Neck Fractures: A Meta-Analysis of 8 Randomized Clinical Trials," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-7, May.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0083422. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.