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Risk Factors for Acute Kidney Injury in Severe Rhabdomyolysis

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  • Eva Rodríguez
  • María J Soler
  • Oana Rap
  • Clara Barrios
  • María A Orfila
  • Julio Pascual

Abstract

Background: Acute kidney injury (AKI) is a life-threatening complication of severe rhabdomyolysis. This study was conducted to assess risk factors for AKI and to develop a risk score for early prediction. Methods: Retrospective observational cohort study with a 9-year follow-up, carried out in an acute-care teaching-affiliated hospital. A total of 126 patients with severe rhabdomyolysis defined as serum creatine kinase (CK) > 5,000 IU/L fulfilled the inclusion criteria. Univariate and logistic regression analyses were performed to determine risk factors for AKI. Based on the values obtained for each variable, a risk score and prognostic probabilities were estimated to establish the risk for developing AKI. Results: The incidence of AKI was 58%. Death during hospitalization was significantly higher among patients with AKI, compared to patients without AKI (19.2% vs 3.6%, p = 0.008). The following variables were independently associated with AKI: peak CK (odds ratio [OR] 4.9, 95%CI 1.4-16.8), hypoalbuminemia (

Suggested Citation

  • Eva Rodríguez & María J Soler & Oana Rap & Clara Barrios & María A Orfila & Julio Pascual, 2013. "Risk Factors for Acute Kidney Injury in Severe Rhabdomyolysis," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-6, December.
    • Handle: RePEc:plo:pone00:0082992
    DOI: 10.1371/journal.pone.0082992
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