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Heritable Influence of DBH on Adrenergic and Renal Function: Twin and Disease Studies

Author

Listed:
  • Dalal N Pasha
  • Jason T Davis
  • Fangwen Rao
  • Yuqing Chen
  • Gen Wen
  • Maple M Fung
  • Manjula Mahata
  • Kuixing Zhang
  • Danuta Trzebinska
  • Maja Mustapic
  • C Makena Hightower
  • Michael S Lipkowitz
  • Ming Ji
  • Michael G Ziegler
  • Caroline M Nievergelt
  • Daniel T O'Connor

Abstract

Background: Elevated sympathetic activity is associated with kidney dysfunction. Here we used twin pairs to probe heritability of GFR and its genetic covariance with other traits. Methods: We evaluated renal and adrenergic phenotypes in twins. GFR was estimated by CKD-EPI algorithm. Heritability and genetic covariance of eGFR and associated risk traits were estimated by variance-components. Meta-analysis probed reproducibility of DBH genetic effects. Effect of DBH genetic variation on renal disease was tested in the NIDDK-AASK cohort. Results: Norepinephrine secretion rose across eGFR tertiles while eGFR fell (p

Suggested Citation

  • Dalal N Pasha & Jason T Davis & Fangwen Rao & Yuqing Chen & Gen Wen & Maple M Fung & Manjula Mahata & Kuixing Zhang & Danuta Trzebinska & Maja Mustapic & C Makena Hightower & Michael S Lipkowitz & Min, 2013. "Heritable Influence of DBH on Adrenergic and Renal Function: Twin and Disease Studies," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-10, December.
    • Handle: RePEc:plo:pone00:0082956
    DOI: 10.1371/journal.pone.0082956
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