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Impact of NPM, TFF3 and TACC1 on the Prognosis of Patients with Primary Gastric Cancer

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Listed:
  • Aiping Ding
  • Wenwen Zhao
  • Xiaoli Shi
  • Ruyong Yao
  • Fang Zhou
  • Lu Yue
  • Shihai Liu
  • Wensheng Qiu

Abstract

Background: NPM, TFF3 and TACC1 are molecular markers that play important roles in cell differentiation. Herein, we investigated their prognostic impact in patients with primary gastric cancer (GC) and determined whether they could be used as markers of more aggressive gastric carcinomas by detecting the extent of expression in human gastric carcinoma samples. Methodology/Principal Findings: Tumor tissue specimens from 142 GC patients were retrospectively retrieved and immunohistochemically evaluated. Correlations between NPM, TFF3 and TACC1 over-expression and clincopathologic parameters, and their prognostic values were investigated with χ2, Kaplan-Meier method, and Cox uni- and multivariate survival models. NPM, TFF3 and TACC1 expression was significantly higher in GC patients with poorly differentiated histologic type than that in patients with well differentiated histologic type. NPM expression was significantly higher in patients with hepatic metastasis or recurrence than that in patients without metastasis. TFF3 expression was significantly higher in patients with positive lymph node metastasis than that in patients with negative lymph node metastasis. Age, lymph node metastasis, and TFF3 and TACC1 over-expression were significantly correlated with low survival (P

Suggested Citation

  • Aiping Ding & Wenwen Zhao & Xiaoli Shi & Ruyong Yao & Fang Zhou & Lu Yue & Shihai Liu & Wensheng Qiu, 2013. "Impact of NPM, TFF3 and TACC1 on the Prognosis of Patients with Primary Gastric Cancer," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-7, December.
    • Handle: RePEc:plo:pone00:0082136
    DOI: 10.1371/journal.pone.0082136
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