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FTO Gene Variant and Risk of Overweight and Obesity among Children and Adolescents: a Systematic Review and Meta-Analysis

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  • Chibo Liu
  • Sihua Mou
  • Yangqun Cai

Abstract

Objective: The fat mass and obesity associated gene (FTO) polymorphisms have been implicated in the susceptibility of overweight/obesity in children and adolescents. However, the results have been inconsistent. In this study, we performed a meta-analysis to clarify the association of FTO gene polymorphisms with overweight/obesity risk among children and adolescents. Methods: PubMed and Embase were used to search for eligible published literatures. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using random- or fixed-effect models. Results: A total of 21 articles containing 23 studies (11208cases and 35015controls) were included in our analysis. The results indicated that variant in FTO gene was significantly associated with increased risk of overweight/obesity in children and adolescents (OR=1.35; 95%CI: 1.27-1.44; P

Suggested Citation

  • Chibo Liu & Sihua Mou & Yangqun Cai, 2013. "FTO Gene Variant and Risk of Overweight and Obesity among Children and Adolescents: a Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-1, November.
    • Handle: RePEc:plo:pone00:0082133
    DOI: 10.1371/journal.pone.0082133
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    1. Bo Xi & Giriraj R Chandak & Yue Shen & Qijuan Wang & Donghao Zhou, 2012. "Association between Common Polymorphism near the MC4R Gene and Obesity Risk: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-7, September.
    2. André Scherag & Christian Dina & Anke Hinney & Vincent Vatin & Susann Scherag & Carla I G Vogel & Timo D Müller & Harald Grallert & H-Erich Wichmann & Beverley Balkau & Barbara Heude & Marjo-Riitta Ja, 2010. "Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups," PLOS Genetics, Public Library of Science, vol. 6(4), pages 1-10, April.
    3. Julia Fischer & Linda Koch & Christian Emmerling & Jeanette Vierkotten & Thomas Peters & Jens C. Brüning & Ulrich Rüther, 2009. "Inactivation of the Fto gene protects from obesity," Nature, Nature, vol. 458(7240), pages 894-898, April.
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