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A Multistage Gene Normalization System Integrating Multiple Effective Methods

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  • Lishuang Li
  • Shanshan Liu
  • Lihua Li
  • Wenting Fan
  • Degen Huang
  • Huiwei Zhou

Abstract

Gene/protein recognition and normalization is an important preliminary step for many biological text mining tasks. In this paper, we present a multistage gene normalization system which consists of four major subtasks: pre-processing, dictionary matching, ambiguity resolution and filtering. For the first subtask, we apply the gene mention tagger developed in our earlier work, which achieves an F-score of 88.42% on the BioCreative II GM testing set. In the stage of dictionary matching, the exact matching and approximate matching between gene names and the EntrezGene lexicon have been combined. For the ambiguity resolution subtask, we propose a semantic similarity disambiguation method based on Munkres' Assignment Algorithm. At the last step, a filter based on Wikipedia has been built to remove the false positives. Experimental results show that the presented system can achieve an F-score of 90.1%, outperforming most of the state-of-the-art systems.

Suggested Citation

  • Lishuang Li & Shanshan Liu & Lihua Li & Wenting Fan & Degen Huang & Huiwei Zhou, 2013. "A Multistage Gene Normalization System Integrating Multiple Effective Methods," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-9, December.
    • Handle: RePEc:plo:pone00:0081956
    DOI: 10.1371/journal.pone.0081956
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