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Low Body Weight in Females Is a Risk Factor for Increased Tenofovir Exposure and Drug-Related Adverse Events

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Listed:
  • Cristina Gervasoni
  • Paola Meraviglia
  • Simona Landonio
  • Sara Baldelli
  • Serena Fucile
  • Laura Castagnoli
  • Emilio Clementi
  • Agostino Riva
  • Massimo Galli
  • Giuliano Rizzardini
  • Dario Cattaneo

Abstract

Treatment with tenofovir sometimes leads to non-reversible kidney and/or bone diseases. Factors associated with these drug-related adverse events are poorly characterized. Our objective was to investigate such factors in patients treated long term with daily tenofovir. One-hundred Caucasian HIV-positive patients with basal creatinine clearance >80 mL/min treated with tenofovir for at least 6 months and with at least one assessment of tenofovir plasma trough concentrations were considered. Tenofovir-associated adverse events were defined as the appearance of pathological proteinuria, worsening of renal function or bone demineralization. By multivariate regression analysis, we found that serum creatinine (p = 0.003) and body weight (p = 0.002) were the factors independently associated with plasma tenofovir concentrations. In particular, women with body weight 50 Kg (160±93 vs.71±52 ng/mL, p

Suggested Citation

  • Cristina Gervasoni & Paola Meraviglia & Simona Landonio & Sara Baldelli & Serena Fucile & Laura Castagnoli & Emilio Clementi & Agostino Riva & Massimo Galli & Giuliano Rizzardini & Dario Cattaneo, 2013. "Low Body Weight in Females Is a Risk Factor for Increased Tenofovir Exposure and Drug-Related Adverse Events," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-6, December.
    • Handle: RePEc:plo:pone00:0080242
    DOI: 10.1371/journal.pone.0080242
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