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Prospective Validation of Immunological Infiltrate for Prediction of Response to Neoadjuvant Chemotherapy in HER2-Negative Breast Cancer – A Substudy of the Neoadjuvant GeparQuinto Trial

Author

Listed:
  • Yasmin Issa-Nummer
  • Silvia Darb-Esfahani
  • Sibylle Loibl
  • Georg Kunz
  • Valentina Nekljudova
  • Iris Schrader
  • Bruno Valentin Sinn
  • Hans-Ullrich Ulmer
  • Ralf Kronenwett
  • Marianne Just
  • Thorsten Kühn
  • Kurt Diebold
  • Michael Untch
  • Frank Holms
  • Jens-Uwe Blohmer
  • Jörg-Olaf Habeck
  • Manfred Dietel
  • Friedrich Overkamp
  • Petra Krabisch
  • Gunter von Minckwitz
  • Carsten Denkert

Abstract

Introduction: We have recently described an increased lymphocytic infiltration rate in breast carcinoma tissue is a significant response predictor for anthracycline/taxane-based neoadjuvant chemotherapy (NACT). The aim of this study was to prospectively validate the tumor-associated lymphocyte infiltrate as predictive marker for response to anthracycline/taxane-based NACT. Patients and Methods: The immunological infiltrate was prospectively evaluated in a total of 313 core biopsies from HER2 negative patients of the multicenter PREDICT study, a substudy of the neoadjuvant GeparQuinto study. Intratumoral lymphocytes (iTuLy), stromal lymphocytes (strLy) as well as lymphocyte-predominant breast cancer (LPBC) were evaluated by histopathological assessment. Pathological complete response (pCR) rates were analyzed and compared between the defined subgroups using the exact test of Fisher. Results: Patients with lymphocyte-predominant breast cancer (LPBC) had a significantly increased pCR rate of 36.6%, compared to non-LPBC patients (14.3%, p

Suggested Citation

  • Yasmin Issa-Nummer & Silvia Darb-Esfahani & Sibylle Loibl & Georg Kunz & Valentina Nekljudova & Iris Schrader & Bruno Valentin Sinn & Hans-Ullrich Ulmer & Ralf Kronenwett & Marianne Just & Thorsten Kü, 2013. "Prospective Validation of Immunological Infiltrate for Prediction of Response to Neoadjuvant Chemotherapy in HER2-Negative Breast Cancer – A Substudy of the Neoadjuvant GeparQuinto Trial," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-7, December.
    • Handle: RePEc:plo:pone00:0079775
    DOI: 10.1371/journal.pone.0079775
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    Cited by:

    1. Yan Mao & Qing Qu & Yuzi Zhang & Junjun Liu & Xiaosong Chen & Kunwei Shen, 2014. "The Value of Tumor Infiltrating Lymphocytes (TILs) for Predicting Response to Neoadjuvant Chemotherapy in Breast Cancer: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(12), pages 1-21, December.

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