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The Risk of Metabolic Syndrome in Patients with Rheumatoid Arthritis: A Meta-Analysis of Observational Studies

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  • Jianming Zhang
  • Lingyu Fu
  • Jingpu Shi
  • Xin Chen
  • Yongze Li
  • Bing Ma
  • Yao Zhang

Abstract

Background: Observational studies suggest an association between the incidence of rheumatoid arthritis (RA) and the prevalence of metabolic syndrome (MetS). However, the relationship between RA and MetS is controversial and research in this area is currently lacking. Objective: The aim of this study was to assess whether the prevalence of MetS was higher in a group of RA patients compared to subjects without RA. Design: A PubMed database search was conducted during April 2013 to identify observational studies of RA and risk of MetS. Reference lists of retrieved articles were also reviewed. Two authors independently extracted information on the study design, the characteristics of the study participants, exposure and outcome assessments, and the method used to control for potential confounding factors. A random-effects model was used for the risk estimates. Results: Our meta-analysis of four cross-sectional controlled studies plus eight case-control studies involving a total of 2283 cases and 4403 controls identified a significant association between RA and risk of MetS, with an overall OR of 1.24 (95% CI, 1.03-1.50). Conclusion: This meta-analysis provides further evidence supporting patients with RA have a higher prevalence of MetS than subjects without RA. In addition, the geographic region of the population and the criteria used for MetS diagnosis could influence the association. However, these observations would need to be evaluated using prospective, randomized studies.

Suggested Citation

  • Jianming Zhang & Lingyu Fu & Jingpu Shi & Xin Chen & Yongze Li & Bing Ma & Yao Zhang, 2013. "The Risk of Metabolic Syndrome in Patients with Rheumatoid Arthritis: A Meta-Analysis of Observational Studies," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-1, October.
    • Handle: RePEc:plo:pone00:0078151
    DOI: 10.1371/journal.pone.0078151
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    Cited by:

    1. Cheng Han & Xue He & Xinghai Xia & Yongze Li & Xiaoguang Shi & Zhongyan Shan & Weiping Teng, 2015. "Subclinical Hypothyroidism and Type 2 Diabetes: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-22, August.
    2. Jamal Hallajzadeh & Saeid Safiri & Mohammad Ali Mansournia & Maliheh Khoramdad & Neda Izadi & Amir Almasi-Hashiani & Reza Pakzad & Erfan Ayubi & Mark J M Sullman & Nahid Karamzad, 2017. "Metabolic syndrome and its components among rheumatoid arthritis patients: A comprehensive updated systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-21, March.
    3. Renee E. Vickman & LaTayia Aaron-Brooks & Renyuan Zhang & Nadia A. Lanman & Brittany Lapin & Victoria Gil & Max Greenberg & Takeshi Sasaki & Gregory M. Cresswell & Meaghan M. Broman & J. Sebastian Pae, 2022. "TNF is a potential therapeutic target to suppress prostatic inflammation and hyperplasia in autoimmune disease," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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