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Prognostic Significance of Circulating Tumor Cells in Non-Small-Cell Lung Cancer Patients: A Meta-Analysis

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  • Jianwei Huang
  • Ke Wang
  • Jianjun Xu
  • Jian Huang
  • Tao Zhang

Abstract

Background: The prognostic significance of circulating tumor cells (CTCs) detected in patients with non-small-cell lung cancer (NSCLC) is still inconsistent. We aimed to assess the prognostic relevance of CTCs using a meta-analysis. Methods: We searched PubMed, Web of Science and EMBASE for relevant studies that assessed the prognostic relevance of CTCs in NSCLC. Statistical analyses were conducted to calculate the summary incidence, odds ratio, relative risks (RRs) and 95% confidence intervals (CIs) using fixed or random-effects models according to the heterogeneity of included studies. Results: A total of 20 studies, comprising 1576 patients, met the inclusion criteria. In identified studies, CTCs were not correlated with histology (adenocarcinoma vs squamous cell carcinoma) (odds ratio [OR] = 0.88; 95% confidence interval [CI]: 0.59–1.33; Z = –0.61; P = 0.545). However, pooled analyses showed that CTCs were associated with lymph node metastasis (OR = 2.06; 95% CI: 1.18–3.62; Z = 2.20; P = 0.027) and tumor stage (OR = 1.95; 95% CI: 1.08–3.54; Z = 2.53; P = 0.011). Moreover, CTCs were significantly associated with shorter overall survival (relative risk [RR] = 2.19; 95% CI: 1.53–3.12; Z = 4.32; P

Suggested Citation

  • Jianwei Huang & Ke Wang & Jianjun Xu & Jian Huang & Tao Zhang, 2013. "Prognostic Significance of Circulating Tumor Cells in Non-Small-Cell Lung Cancer Patients: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-8, November.
    • Handle: RePEc:plo:pone00:0078070
    DOI: 10.1371/journal.pone.0078070
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    References listed on IDEAS

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    1. Sunitha Nagrath & Lecia V. Sequist & Shyamala Maheswaran & Daphne W. Bell & Daniel Irimia & Lindsey Ulkus & Matthew R. Smith & Eunice L. Kwak & Subba Digumarthy & Alona Muzikansky & Paula Ryan & Ulyss, 2007. "Isolation of rare circulating tumour cells in cancer patients by microchip technology," Nature, Nature, vol. 450(7173), pages 1235-1239, December.
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    1. Yunlan Zhou & Bingxian Bian & Xiangliang Yuan & Guohua Xie & Yanhui Ma & Lisong Shen, 2015. "Prognostic Value of Circulating Tumor Cells in Ovarian Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-14, June.

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