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Meta-Analysis on the Associations of TLR2 Gene Polymorphisms with Pulmonary Tuberculosis Susceptibility among Asian Populations

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  • Jia-Jia Wang
  • Xian Xia
  • Shai-Di Tang
  • Jie Wang
  • Xiao-Zhao Deng
  • Yun Zhang
  • Ming Yue

Abstract

Background: Publications regarding the associations of toll-like receptor 2 (TLR2) G2258A and T597C polymorphisms with pulmonary tuberculosis (PTB) susceptibility are inconsistent. A meta-analysis was conducted to investigate the relationship between TLR2 G2258A and T597C polymorphisms with PTB susceptibility. Methods: A systematic search was performed for published studies on the relationship between TLR2 polymorphisms and PTB susceptibility. Information was gathered from each eligible study, and statistically analyzed. Results: 6 eligible studies, totaling 1301 cases and 1217 controls on G2258A genotypes, and 8 studies, totaling 2175 cases and 2069 controls on T597C genotypes, were included in the analysis. TLR2 2258G allele and 2258GG genotype were found to be associated with decreased PTB susceptibility (A vs. G: OR = 3.02, 95% CI: 2.22–4.12, P

Suggested Citation

  • Jia-Jia Wang & Xian Xia & Shai-Di Tang & Jie Wang & Xiao-Zhao Deng & Yun Zhang & Ming Yue, 2013. "Meta-Analysis on the Associations of TLR2 Gene Polymorphisms with Pulmonary Tuberculosis Susceptibility among Asian Populations," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-6, October.
    • Handle: RePEc:plo:pone00:0075090
    DOI: 10.1371/journal.pone.0075090
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    1. Masahiro Yamamoto & Shintaro Sato & Hiroaki Hemmi & Hideki Sanjo & Satoshi Uematsu & Tsuneyasu Kaisho & Katsuaki Hoshino & Osamu Takeuchi & Masaya Kobayashi & Takashi Fujita & Kiyoshi Takeda & Shizuo , 2002. "Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4," Nature, Nature, vol. 420(6913), pages 324-329, November.
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    Cited by:

    1. Haiko Schurz & Michelle Daya & Marlo Möller & Eileen G Hoal & Muneeb Salie, 2015. "TLR1, 2, 4, 6 and 9 Variants Associated with Tuberculosis Susceptibility: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-24, October.
    2. Xuan Gao & Junjun Chen & Zhongkai Tong & Guangdie Yang & Yinan Yao & Fei Xu & Jianying Zhou, 2015. "Interleukin-10 Promoter Gene Polymorphisms and Susceptibility to Tuberculosis: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-16, June.

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