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The Plasma Mitochondrial DNA Is an Independent Predictor for Post-Traumatic Systemic Inflammatory Response Syndrome

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  • Xiaoling Gu
  • Yanwen Yao
  • Guannan Wu
  • Tangfeng Lv
  • Liang Luo
  • Yong Song

Abstract

Background and Purpose: Mitochondrial DNA (mtDNA), a newly identified damage-associated molecular pattern, has been observed in trauma patients, however, little is known concerning the relationship between plasma mtDNA levels and concrete post-traumatic complications, particularly systemic inflammatory response syndrome (SIRS). The aim of this study is to determine whether plasma mtDNA levels are associated with injury severity and cloud predict post-traumatic SIRS in patients with acute traumatic injury. Patients and Methods: Eighty-six consecutive patients with acute traumatic injury were prospectively enrolled in this study. The plasma mtDNA concentration was measured by a real-time, quantitative PCR assay for the human ND2 gene. The study population’s clinical and laboratory data were analyzed. Results: The median plasma mtDNA was higher in trauma patients than in healthy controls (865.196 (251.042-2565.40)pg/ml vs 64.2147 (43.9049-80.6371)pg/ml, P

Suggested Citation

  • Xiaoling Gu & Yanwen Yao & Guannan Wu & Tangfeng Lv & Liang Luo & Yong Song, 2013. "The Plasma Mitochondrial DNA Is an Independent Predictor for Post-Traumatic Systemic Inflammatory Response Syndrome," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-1, August.
    • Handle: RePEc:plo:pone00:0072834
    DOI: 10.1371/journal.pone.0072834
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    References listed on IDEAS

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    1. Qin Zhang & Mustafa Raoof & Yu Chen & Yuka Sumi & Tolga Sursal & Wolfgang Junger & Karim Brohi & Kiyoshi Itagaki & Carl J. Hauser, 2010. "Circulating mitochondrial DAMPs cause inflammatory responses to injury," Nature, Nature, vol. 464(7285), pages 104-107, March.
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    Cited by:

    1. Jonatan A. Mendoza-Ortega & Enrique Reyes-Muñoz & Sonia Nava-Salazar & Sandra Rodríguez-Martínez & Sandra B. Parra-Hernández & Lourdes Schnaas & Blanca Vianey Suárez-Rico & Libni A. Torres-Olascoaga &, 2021. "Mitochondrial DNA Copy Number Adaptation as a Biological Response Derived from an Earthquake at Intrauterine Stage," IJERPH, MDPI, vol. 18(22), pages 1-10, November.

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