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The −842G/C Polymorphisms of PIN1 Contributes to Cancer Risk: A Meta-Analysis of 10 Case-Control Studies

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  • Hui-Rong Xu
  • Zhong-Fa Xu
  • Yan-Lai Sun
  • Jian-Jun Han
  • Zeng-Jun Li

Abstract

Background: Peptidyl-prolyl cis–trans isomerase NIMA-interacting 1 (PIN1) plays an important role in cancer development. The relationship between PIN1 −842G/C (rs2233678) polymorphism and cancer risk was inconclusive according to published literature. Methodology/Principal Findings: A literature search, up to February 2013, was carried out using PubMed, EMBASE and the China National Knowledge Infrastructure (CNKI) database. A total of 10 case-control studies including 4619 cases and 4661 controls contributed to the quantitative analysis. Odds ratio (OR) and 95% confidence intervals (95% CI) were used to assess the strength of association. Overall, individuals with the variant CG (OR = 0.728, 95% CI: 0.585,0.906; Pheterogeneity

Suggested Citation

  • Hui-Rong Xu & Zhong-Fa Xu & Yan-Lai Sun & Jian-Jun Han & Zeng-Jun Li, 2013. "The −842G/C Polymorphisms of PIN1 Contributes to Cancer Risk: A Meta-Analysis of 10 Case-Control Studies," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-7, August.
  • Handle: RePEc:plo:pone00:0071516
    DOI: 10.1371/journal.pone.0071516
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    References listed on IDEAS

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