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Efficacy and Safety Profile of Combining Vandetanib with Chemotherapy in Patients with Advanced Non-Small Cell Lung Cancer: A Meta-Analysis

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Listed:
  • Wei Tian
  • Wenping Ding
  • Sungkyoung Kim
  • Leizhen Zheng
  • Li Zhang
  • Xiaoping Li
  • Jianchun Gu
  • Lian Zhang
  • Minggui Pan
  • Siyu Chen

Abstract

Objective: To evaluate the efficacy and safety profile of combining vandetanib with chemotherapy in patients with advanced non-small cell lung cancer (NSCLC). Methods: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), ASCO Abstracts, ESMO Abstracts, Wanfang Database, CNKI were searched. Eligible studies were the randomized clinical trials (RCTs) that compared the efficacy and safety profile of adding vandetanib to chemotherapy with single chemotherapy in patients with advanced NSCLC. The outcomes included overall survival (OS), progression-free survival (PFS), overall response rate (ORR) and toxicities. All meta-analysis were performed using Review Manager 5.1. The fixed-effect model weighted by the Mantel-Haenszel method was used. When considerable heterogeneity was found (p 50%), further analysis (subgroup analysis, sensitivity analysis or random-effect model) was performed to identify potential cause. Results: Results reported from 5 RCTs involving 2284 patients were included in the analysis. Compared to chemotherapy alone, the addition of vandetanib resulted in a significant longer PFS (HR 0.79 [0.72–0.87], p

Suggested Citation

  • Wei Tian & Wenping Ding & Sungkyoung Kim & Leizhen Zheng & Li Zhang & Xiaoping Li & Jianchun Gu & Lian Zhang & Minggui Pan & Siyu Chen, 2013. "Efficacy and Safety Profile of Combining Vandetanib with Chemotherapy in Patients with Advanced Non-Small Cell Lung Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-10, July.
    • Handle: RePEc:plo:pone00:0067929
    DOI: 10.1371/journal.pone.0067929
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    References listed on IDEAS

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    1. André Bacellar Costa Lima & Ligia T Macedo & André Deeke Sasse, 2011. "Addition of Bevacizumab to Chemotherapy in Advanced Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 6(8), pages 1-8, August.
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