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Adiponectin-11377CG Gene Polymorphism and Type 2 Diabetes Mellitus in the Chinese Population: A Meta-Analysis of 6425 Subjects

Author

Listed:
  • Yan-yan Li
  • Zhi-jian Yang
  • Chuan-wei Zhou
  • Xiang-ming Wang
  • Yun Qian
  • Jian Xu
  • Bei Wang
  • Jun Wu

Abstract

Background: Although adiponectin −11377CG gene polymorphism is implied to be associated with increased type 2 diabetes mellitus (T2DM) risk, results of individual studies are inconsistent. Objective and Methods: A meta-analysis consisting of 12 individual studies, including a total of 6425 participants, was carried out in order to investigate the association of adiponectin −11377CG gene polymorphism with T2DM. The pooled odds ratio (OR) and its corresponding confidence interval (CI) at 95% were assessed through the random- or fixed- effect model. Results: A significant relationship was observed between adiponectin −11377CG gene polymorphism and T2DM under allelic (OR: 1.150, 95% CI: 1.060 to 1.250, P = 0.001), recessive (OR: 1.450, 95% CI: 1.180–1.770, P = 0.0004), dominant (OR: 1.071, 95% CI: 1.013–1.131, P = 0.015), additive (OR: 1.280, 95% CI: 1.090–1.510, P = 0.002), and homozygous genetic models (OR: 1.620, 95% CI: 1.310–1.990, P

Suggested Citation

  • Yan-yan Li & Zhi-jian Yang & Chuan-wei Zhou & Xiang-ming Wang & Yun Qian & Jian Xu & Bei Wang & Jun Wu, 2013. "Adiponectin-11377CG Gene Polymorphism and Type 2 Diabetes Mellitus in the Chinese Population: A Meta-Analysis of 6425 Subjects," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-10, April.
    • Handle: RePEc:plo:pone00:0061153
    DOI: 10.1371/journal.pone.0061153
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    Cited by:

    1. Ling Qiu & Risu Na & Rong Xu & Siyang Wang & Hongguang Sheng & Wanling Wu & Yi Qu, 2014. "Quantitative Assessment of the Effect of KCNJ11 Gene Polymorphism on the Risk of Type 2 Diabetes," PLOS ONE, Public Library of Science, vol. 9(4), pages 1-9, April.

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