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Decreased Expression of Beclin 1 Correlates Closely with Bcl-xL Expression and Poor Prognosis of Ovarian Carcinoma

Author

Listed:
  • Huan-Xin Lin
  • Hui-Juan Qiu
  • Fei Zeng
  • Hui-Lan Rao
  • Guo-Fen Yang
  • Hsiang-Fu Kung
  • Xiao-Feng Zhu
  • Yi-Xin Zeng
  • Mu-Yan Cai
  • Dan Xie

Abstract

Background: It has been suggested that autophagy-related Beclin 1 plays a critical role in the regulation of tumor development and/or progression, but its prognostic significance and relationship with Bcl-xL expression in ovarian carcinoma are unclear. Methodology/Principal Findings: In the present study, the methods of Western blotting and immunohistochemistry (IHC) were utilized to investigate the expression status of Beclin 1 and Bcl-xL in fresh ovarian tissues and paraffin-embedded epithelial ovarian tumor tissues. Decreased expression of Beclin 1 was examined by IHC in 8.3% of normal ovaries, in 15.4% of cystadenomas, in 20.0% of borderline tumors, and in 55.6% of ovarian carcinomas, respectively. In ovarian carcinomas, decreased expression of Beclin 1 was correlated closely with ascending histological grade, later pT/pN/pM status and/or advanced clinical stage (P

Suggested Citation

  • Huan-Xin Lin & Hui-Juan Qiu & Fei Zeng & Hui-Lan Rao & Guo-Fen Yang & Hsiang-Fu Kung & Xiao-Feng Zhu & Yi-Xin Zeng & Mu-Yan Cai & Dan Xie, 2013. "Decreased Expression of Beclin 1 Correlates Closely with Bcl-xL Expression and Poor Prognosis of Ovarian Carcinoma," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-10, April.
    • Handle: RePEc:plo:pone00:0060516
    DOI: 10.1371/journal.pone.0060516
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