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Association of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) Polymorphisms in TCF7L2 with Type 2 Diabetes in 9,619 Han Chinese Population

Author

Listed:
  • Jinjin Wang
  • Linlin Li
  • Jiatong Zhang
  • Jing Xie
  • Xinping Luo
  • Dahai Yu
  • Jingzhi Zhao
  • Tianping Feng
  • Chao Pang
  • Lei Yin
  • Fulan Hu
  • Jianfeng Zhang
  • Yan Wang
  • Qian Wang
  • Yujia Zhai
  • Haifei You
  • Tian Zhu
  • Dongsheng Hu

Abstract

Aims: We aimed to replicate the association of the rs290487 (IVS3C/T) and rs7903146 (IVS3C/T) polymorphisms of transcription factor 7-like 2 (TCF7L2) and type 2 diabetes mellitus (T2DM) in Han Chinese people in Henan province, China. Methods: In all, 1,842 patients with T2DM and 7,777 normal glucose-tolerant controls underwent genotyping for the T2DM-associated variants rs7903146 (IVS3C/T) and rs290487 (IVS3C/T). W performed a meta-analysis of the association of the risk alleles of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) in TCF7L2 and T2DM in Han Chinese by combining previous studies with the present study. Results: We found that T2DM was associated with the CC genotype (1.364, 1.137–1.636, p = 0.001), the recessive model (1.457, 1.156–1.838, p = 0.001) of rs290487 (IVS3C/T) and haplotype CC (1.116, 1.034–1.204, p = 0.004) in Han Chinese. Moreover, our meta-analyses supported the association of the T allele (IVS3C/T) of rs7903146 (1.36, 1.24–1.48; p = 6.404×10−12) and T2DM but not the C allele of rs290487 (IVS3C/T) (0.99, 0.85–1.15, p = 0.890) in Han Chinese. We found no interactions between behavioral risk factors (smoking, alcohol drinking, and physical activity) and rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) polymorphisms. Conclusions: The CC genotype and the recessive model of the variant rs290487 (IVS3C/T) and CC haplotype of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) in TCF7L2 may be associated with T2DM in Han Chinese people in Henan province, China.

Suggested Citation

  • Jinjin Wang & Linlin Li & Jiatong Zhang & Jing Xie & Xinping Luo & Dahai Yu & Jingzhi Zhao & Tianping Feng & Chao Pang & Lei Yin & Fulan Hu & Jianfeng Zhang & Yan Wang & Qian Wang & Yujia Zhai & Haife, 2013. "Association of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) Polymorphisms in TCF7L2 with Type 2 Diabetes in 9,619 Han Chinese Population," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-5, March.
    • Handle: RePEc:plo:pone00:0059053
    DOI: 10.1371/journal.pone.0059053
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