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Factors Associated with Lung Function Decline in Patients with Non-Tuberculous Mycobacterial Pulmonary Disease

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Listed:
  • Meng-Rui Lee
  • Ching-Yao Yang
  • Kai-Ping Chang
  • Li-Ta Keng
  • David Hung-Tsang Yen
  • Jann-Yuan Wang
  • Huey-Dong Wu
  • Li-Na Lee
  • Chong-Jen Yu

Abstract

Background: There is paucity of risk factors on lung function decline among patients with non-tuberculous mycobacteria (NTM) pulmonary disease in literature. Methods: Patients with NTM pulmonary disease between January 2000 and April 2011 were retrospectively selected. Sixty-eight patients had at least two pulmonary function tests within a mean follow-up period of 47 months. Results: Sixty-eight patients were included. They had a median age of 65 years and 65% had impaired lung function (Forced expiratory volume in 1 second [FEV1] 50% of predicted value (beta: 0.349, p = 0.002), male sex (beta: 0.295, p = 0.018), bronchiectasis pattern (beta: 0.232, p = 0.035), and radiographic score >3 (beta: 0.217, p = 0.049) were associated with greater FEV1 decline. Initial FEV1>50% of predicted value (beta: 0.263, p = 0.032) was also associated with greater FVC annual decline, whereas M. kansasii pulmonary disease was marginally associated with greater annual FVC decline (beta: 0.227, p = 0.062). Conclusions: NTM pulmonary disease is associated with greater decline in lung function in patients who are young, male, with bronchiectasis, and with a high radiographic score. Special attention should be given to patients with these risk factors.

Suggested Citation

  • Meng-Rui Lee & Ching-Yao Yang & Kai-Ping Chang & Li-Ta Keng & David Hung-Tsang Yen & Jann-Yuan Wang & Huey-Dong Wu & Li-Na Lee & Chong-Jen Yu, 2013. "Factors Associated with Lung Function Decline in Patients with Non-Tuberculous Mycobacterial Pulmonary Disease," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-6, March.
    • Handle: RePEc:plo:pone00:0058214
    DOI: 10.1371/journal.pone.0058214
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