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Association of SMAD7 rs12953717 Polymorphism with Cancer: A Meta-Analysis

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  • Hongtuan Zhang
  • Hui Ma
  • Yong Xu
  • Liang Li

Abstract

Background: Accumulating evidence has suggested that Mothers against decapentaplegic homolog 7 (SMAD7) rs12953717 polymorphism might be related to cancer risk. However, epidemiologic findings have been inconsistent. We therefore performed a meta-analysis to clarify the association between the SMAD7 rs12953717 polymorphism and cancer risk. Methods: A comprehensive search was conducted to identify all eligible studies of SMAD7 rs12953717 polymorphism and cancer risk. We used odds ratios (ORs) to assess the strength of the association, and 95% confidence intervals (CIs) to give a sense of the precision of the estimate. Heterogeneity, publication bias, and sensitivity analysis were also explored. Results: A total of 14 case-control studies, including 16928 cases and 14781 controls, were included in the present meta-analysis. The overall results showed that the variant genotypes were associated with a significantly increased risk of all cancer types (homozygote comparison, OR = 1.23, 95%CI = 1.10–1.38, P

Suggested Citation

  • Hongtuan Zhang & Hui Ma & Yong Xu & Liang Li, 2013. "Association of SMAD7 rs12953717 Polymorphism with Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-7, March.
    • Handle: RePEc:plo:pone00:0058170
    DOI: 10.1371/journal.pone.0058170
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