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Time Course of Current of Injury Is Related to Acute Stability of Active-Fixation Pacing Leads in Rabbits

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  • Shalaimaiti Shali
  • Alimujiang Wushou
  • Entao Liu
  • Lin Jia
  • Ruiming Yao
  • Yangang Su
  • Junbo Ge

Abstract

Background: Magnitude of current of injury (COI) consequent to pacemaker lead fixation is recognized as a predictor of acute lead stability. It is unclear whether dynamic monitoring of COI after lead fixation provides additional information beyond a single assessment performed at the time of fixation. Objectives: This study was aimed to test the hypothesis that the time course of COI is related to acute lead stability. Methods and Results: Active fixation leads with fixed screw were anchored to either Langendorff-perfused rabbit hearts endocardially or in vivo hearts epicardially in manners of contact the helix with no rotation, half rotation and full rotation, respectively. Intracardiac electrogram (EGM) was monitored dynamically from onset to resolution of COI, and magnitudes of intrinsic R wave and COI, including ST-segment elevation, ST/R and intracardiac EGM duration (IED), were measured. A digital force gauge was applied to assess lead stability. In vitro, COI in contacted leads was significantly smaller than those in half rotated (p

Suggested Citation

  • Shalaimaiti Shali & Alimujiang Wushou & Entao Liu & Lin Jia & Ruiming Yao & Yangang Su & Junbo Ge, 2013. "Time Course of Current of Injury Is Related to Acute Stability of Active-Fixation Pacing Leads in Rabbits," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-7, March.
    • Handle: RePEc:plo:pone00:0057727
    DOI: 10.1371/journal.pone.0057727
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