IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0056397.html
   My bibliography  Save this article

Rapid Inverse Planning for Pressure-Driven Drug Infusions in the Brain

Author

Listed:
  • Kathryn H Rosenbluth
  • Alastair J Martin
  • Stephan Mittermeyer
  • Jan Eschermann
  • Peter J Dickinson
  • Krystof S Bankiewicz

Abstract

Infusing drugs directly into the brain is advantageous to oral or intravenous delivery for large molecules or drugs requiring high local concentrations with low off-target exposure. However, surgeons manually planning the cannula position for drug delivery in the brain face a challenging three-dimensional visualization task. This study presents an intuitive inverse-planning technique to identify the optimal placement that maximizes coverage of the target structure while minimizing the potential for leakage outside the target. The technique was retrospectively validated using intraoperative magnetic resonance imaging of infusions into the striatum of non-human primates and into a tumor in a canine model and applied prospectively to upcoming human clinical trials.

Suggested Citation

  • Kathryn H Rosenbluth & Alastair J Martin & Stephan Mittermeyer & Jan Eschermann & Peter J Dickinson & Krystof S Bankiewicz, 2013. "Rapid Inverse Planning for Pressure-Driven Drug Infusions in the Brain," PLOS ONE, Public Library of Science, vol. 8(2), pages 1-6, February.
    • Handle: RePEc:plo:pone00:0056397
    DOI: 10.1371/journal.pone.0056397
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0056397
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0056397&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0056397?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0056397. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.