IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0053322.html
   My bibliography  Save this article

A Possible Genetic Link between MTHFR Genotype and Smoking Behavior

Author

Listed:
  • Michael Linnebank
  • Susanna Moskau
  • Alexander Semmler
  • Barbara Hoefgen
  • Gisela Bopp
  • Ulf Kallweit
  • Wolfgang Maier
  • Christian G Schütz
  • Ullrich Wüllner

Abstract

Background: Hyperhomocysteinemia is an independent risk factor for stroke and other vascular events. The variant methylenetetrahydrofolate reductase (MTHFR) C677T is associated with elevated homocysteine levels, cardiovascular disease and stroke, which supports a causal relationship between hyperhomocysteinemia and vascular disease. However, MTHFR variants have also been reported to be associated with smoking behavior, which could be an important confounder. Methodology/Principal Findings: We analyzed the MTHFR variants C677T and A1298C in two independent samples of 525 and 535 individuals, respectively. 21% of the non-smokers, but only 12% of the smokers were homozygous carriers of both MTHFR wildtype alleles, i.e. 677CC and 1298AA (Chi2 = 15.8; p

Suggested Citation

  • Michael Linnebank & Susanna Moskau & Alexander Semmler & Barbara Hoefgen & Gisela Bopp & Ulf Kallweit & Wolfgang Maier & Christian G Schütz & Ullrich Wüllner, 2012. "A Possible Genetic Link between MTHFR Genotype and Smoking Behavior," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-4, December.
    • Handle: RePEc:plo:pone00:0053322
    DOI: 10.1371/journal.pone.0053322
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0053322
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0053322&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0053322?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0053322. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.