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Feasibility of Azacitidine Added to Standard Chemotherapy in Older Patients with Acute Myeloid Leukemia — A Randomised SAL Pilot Study

Author

Listed:
  • Utz Krug
  • Anja Koschmieder
  • Daniela Schwammbach
  • Joachim Gerss
  • Nicola Tidow
  • Björn Steffen
  • Gesine Bug
  • Christian H Brandts
  • Markus Schaich
  • Christoph Röllig
  • Christian Thiede
  • Richard Noppeney
  • Matthias Stelljes
  • Thomas Büchner
  • Steffen Koschmieder
  • Ulrich Dührsen
  • Hubert Serve
  • Gerhard Ehninger
  • Wolfgang E Berdel
  • Carsten Müller-Tidow

Abstract

Introduction: Older patients with acute myeloid leukemia (AML) experience short survival despite intensive chemotherapy. Azacitidine has promising activity in patients with low proliferating AML. The aim of this dose-finding part of this trial was to evaluate feasibility and safety of azacitidine combined with a cytarabine- and daunorubicin-based chemotherapy in older patients with AML. Trial Design: Prospective, randomised, open, phase II trial with parallel group design and fixed sample size. Patients and Methods: Patients aged 61 years or older, with untreated acute myeloid leukemia with a leukocyte count of

Suggested Citation

  • Utz Krug & Anja Koschmieder & Daniela Schwammbach & Joachim Gerss & Nicola Tidow & Björn Steffen & Gesine Bug & Christian H Brandts & Markus Schaich & Christoph Röllig & Christian Thiede & Richard Nop, 2012. "Feasibility of Azacitidine Added to Standard Chemotherapy in Older Patients with Acute Myeloid Leukemia — A Randomised SAL Pilot Study," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-8, December.
    • Handle: RePEc:plo:pone00:0052695
    DOI: 10.1371/journal.pone.0052695
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