IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0052638.html
   My bibliography  Save this article

Predictive Value of Clinical Judgment of Tumour Progression in Phase II Trials

Author

Listed:
  • Nuria Kotecki
  • Nicolas Penel
  • Antoine Adenis
  • Charles Ferte
  • Stéphanie Clisant

Abstract

Background: The diagnosis of tumour progression or progressive disease (PD) is a key element for designing and interpreting contemporary phase II trials. In some cases, PD is stated by the physician and is not formally confirmed by imaging. Purpose: In this study, we intend to analyze the value of the PD based on clinical judgment and the risk of overestimating the occurrence of PD by clinical judgment. Methods: We have conducted a single-centre retrospective study to analyse the diagnostic accuracy of this clinical judgment compared to planned imaging including all patients enrolled in our institution in phase II trials investigating systemic treatments for advanced solid tumours between January 2008 and November 2010. Results: The positive predictive value (PPV) and the specificity of clinical judgment of PD was very high (>90%). Conclusions: According to this study, the clinical judgment of PD is highly predictive of radiological PD as assessed, for example, by RECIST. Physicians do not overestimate PD occurence. Clinical judgment of PD could be taken into account in the definition of PD.

Suggested Citation

  • Nuria Kotecki & Nicolas Penel & Antoine Adenis & Charles Ferte & Stéphanie Clisant, 2012. "Predictive Value of Clinical Judgment of Tumour Progression in Phase II Trials," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-4, December.
    • Handle: RePEc:plo:pone00:0052638
    DOI: 10.1371/journal.pone.0052638
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0052638
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0052638&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0052638?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0052638. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.