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MiR-27 as a Prognostic Marker for Breast Cancer Progression and Patient Survival

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  • Wei Tang
  • Jiujun Zhu
  • Shicheng Su
  • Wei Wu
  • Qiang Liu
  • Fengxi Su
  • Fengyan Yu

Abstract

Background: MicroRNA-27a (miR-27a) is thought to be an onco-microRNA that promotes tumor growth and metastasis by downregulating ZBTB10. The potential predictive value of miR-27a was studied in breast cancer patients. Methods: The expression of miR-27a and ZBTB10 was examined in 102 breast cancer cases using in situ hybridization (ISH) and immunohistochemistry techniques and were evaluated semi-quantitatively by examining the staining index. The Correlation of miR-27a and ZBTB10 expression was analyed by Spearman Rank Correlation. The association of miR-27a and ZBTB10 expression with clinicopathological characteristics was analyzed using the χ2 test, and their effects on patient survival were analyzed by a log-rank test and the Kaplan-Meier method. Univariate and multivariate Cox regression analyses were used to evaluate the prognostic values of miR-27a and ZBTB10. Results: miR-27a was markedly up-regulated in invasive breast cancers that expressed low levels of ZBTB10 (P

Suggested Citation

  • Wei Tang & Jiujun Zhu & Shicheng Su & Wei Wu & Qiang Liu & Fengxi Su & Fengyan Yu, 2012. "MiR-27 as a Prognostic Marker for Breast Cancer Progression and Patient Survival," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-7, December.
    • Handle: RePEc:plo:pone00:0051702
    DOI: 10.1371/journal.pone.0051702
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    Cited by:

    1. Rongrong Zheng & Shaofeng Wu & Xiangfeng Jin & Yuhong Liu, 2018. "Effect of miR-27a-3p on Proliferation and Migration in Non-small Cell Lung Cancer Cells," International Journal of Sciences, Office ijSciences, vol. 7(03), pages 94-101, March.

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