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Pneumococcal Pneumonia and the Risk of Stroke: A Population-Based Follow-Up Study

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  • Li-Fu Chen
  • Hsin-Pai Chen
  • Yung-Sung Huang
  • Kuang-Yung Huang
  • Pesus Chou
  • Ching-Chih Lee

Abstract

Background: To investigate the risk of developing stroke in patients hospitalized following a diagnosis of pneumococcal pneumonia. Methods: The study cohorts comprised of patients hospitalized with a principal diagnosis of pneumococcal pneumonia (n = 745), with a random sampling of control individuals in 2004 (n = 1490). The Cox proportional hazard model was used to compare the stroke-free survival rate between the cohorts after adjusting for possible confounding and risk factors for a two-year follow up. Instrumental variable analysis (IVA) was used to address potential biases associated with measured and unmeasured confounding variables. Results: Of the 153 patients with stroke, 80 (10.7%) were from the pneumococcal pneumonia cohort, and 73 (4.9%) were from the control group. The risk of stroke was 3.65 times higher (95% confidence interval, 2.25–5.90; P

Suggested Citation

  • Li-Fu Chen & Hsin-Pai Chen & Yung-Sung Huang & Kuang-Yung Huang & Pesus Chou & Ching-Chih Lee, 2012. "Pneumococcal Pneumonia and the Risk of Stroke: A Population-Based Follow-Up Study," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-7, December.
    • Handle: RePEc:plo:pone00:0051452
    DOI: 10.1371/journal.pone.0051452
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