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Development of Eye Position Dependency of Slow Phase Velocity during Caloric Stimulation

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  • Christopher J Bockisch
  • Elham Khojasteh
  • Dominik Straumann
  • Stefan C A Hegemann

Abstract

The nystagmus in patients with vestibular disorders often has an eye position dependency, called Alexander’s law, where the slow phase velocity is higher with gaze in the fast phase direction compared with gaze in the slow phase direction. Alexander’s law has been hypothesized to arise either due to adaptive changes in the velocity-to-position neural integrator, or as a consequence of processing of the vestibular-ocular reflex. We tested whether Alexander’s law arises only as a consequence of non-physiologic vestibular stimulation. We measured the time course of the development of Alexander’s law in healthy humans with nystagmus caused by three types of caloric vestibular stimulation: cold (unilateral inhibition), warm (unilateral excitation), and simultaneous bilateral bithermal (one side cold, the other warm) stimulation, mimicking the normal push-pull pattern of vestibular stimulation. Alexander’s law, measured as a negative slope of the velocity versus position curve, was observed in all conditions. A reversed pattern of eye position dependency (positive slope) was found

Suggested Citation

  • Christopher J Bockisch & Elham Khojasteh & Dominik Straumann & Stefan C A Hegemann, 2012. "Development of Eye Position Dependency of Slow Phase Velocity during Caloric Stimulation," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-8, December.
    • Handle: RePEc:plo:pone00:0051409
    DOI: 10.1371/journal.pone.0051409
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