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Depressive Symptoms and the Risk of Ischemic Stroke in the Elderly—Influence of Age and Sex

Author

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  • Christian L Seifert
  • Holger Poppert
  • Dirk Sander
  • Regina Feurer
  • Thorleif Etgen
  • Karl-Heinz Ander
  • Klaus Pürner
  • Monika Brönner
  • Dominik Sepp
  • Victoria Kehl
  • Hans Förstl
  • Horst Bickel

Abstract

Although a relationship between depression and cardiovascular events has been suggested, past study results regarding the risk of stroke in relation to depression by subgroups are ambiguous. The aim of this study was to investigate the influence of depressive symptoms on risk of incident ischemic stroke in elderly according to age and sex. This prospective cohort study followed up 3852 subjects older than 55 years. Baseline depressive symptoms were defined by a score ≥5 on the Geriatric Depression Scale or antidepressant intake. The outcome measure was incident ischemic stroke within 6 years of follow-up. Multivariate Cox-proportional hazard models as well as cumulative survival analyses were computed. A total of 156 ischemic strokes occurred during the study period (24 strokes in the age-group

Suggested Citation

  • Christian L Seifert & Holger Poppert & Dirk Sander & Regina Feurer & Thorleif Etgen & Karl-Heinz Ander & Klaus Pürner & Monika Brönner & Dominik Sepp & Victoria Kehl & Hans Förstl & Horst Bickel, 2012. "Depressive Symptoms and the Risk of Ischemic Stroke in the Elderly—Influence of Age and Sex," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-7, November.
    • Handle: RePEc:plo:pone00:0050803
    DOI: 10.1371/journal.pone.0050803
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