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An Investigation of Age-Related Iron Deposition Using Susceptibility Weighted Imaging

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  • Dan Wang
  • Wen-Bin Li
  • Xiao-Er Wei
  • Yue-Hua Li
  • Yong-Ming Dai

Abstract

Aim: To quantify age-dependent iron deposition changes in healthy subjects using Susceptibility Weighted Imaging (SWI). Materials and Methods: In total, 143 healthy volunteers were enrolled. All underwent conventional MR and SWI sequences. Subjects were divided into eight groups according to age. Using phase images to quantify iron deposition in the head of the caudate nucleus and the lenticular nucleus, the angle radian value was calculated and compared between groups. ANOVA/Pearson correlation coefficient linear regression analysis and polynomial fitting were performed to analyze the relationship between iron deposition in the head of the caudate nucleus and lenticular nucleus with age. Results: Iron deposition in the lenticular nucleus increased in individuals aged up to 40 years, but did not change in those aged over 40 years once a peak had been reached. In the head of the caudate nucleus, iron deposition peaked at 60 years (p

Suggested Citation

  • Dan Wang & Wen-Bin Li & Xiao-Er Wei & Yue-Hua Li & Yong-Ming Dai, 2012. "An Investigation of Age-Related Iron Deposition Using Susceptibility Weighted Imaging," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-7, November.
    • Handle: RePEc:plo:pone00:0050706
    DOI: 10.1371/journal.pone.0050706
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