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Association between Leukocyte and Metabolic Syndrome in Urban Han Chinese: A Longitudinal Cohort Study

Author

Listed:
  • Wenjia Meng
  • Chengqi Zhang
  • Qian Zhang
  • Xinhong Song
  • Haiyan Lin
  • Dongzhi Zhang
  • Yongyuan Zhang
  • Zhenxin Zhu
  • Shuo Wu
  • Yanxun Liu
  • Fang Tang
  • Xiaowei Yang
  • Fuzhong Xue

Abstract

Background: Although cross-sectional studies have shown that leukocyte is linked with metabolic syndrome (MetS), few longitudinal or cohort studies have been used to confirm this relationship. We therefore conducted a large-scale health check-up longitudinal cohort in urban Chinese population from middle to upper socioeconomic strata to investigate and prove the association between the total leukocyte/its subtypes and MetS/its components (obesity, hyperglycemia, dyslipidemia, and hypertension). Methods: A longitudinal cohort study was established in 2005 on individuals who were middle-to-upper class urban Chinese. Data used in this investigation was based on 6,513 participants who had at least three routine health check-ups over a period of six-year follow-up. Data analysis was conducted through generalized estimating equation (GEE) model. Results: A total of 255 cases of MetS occurred over the six-year follow-up, leading to a total incidence density of 11.45 per 1,000 person-years (255/22279 person-years). The total leukocyte was markedly associated with MetS (RR = 2.66, 95%CI = 1.81–3.90], p

Suggested Citation

  • Wenjia Meng & Chengqi Zhang & Qian Zhang & Xinhong Song & Haiyan Lin & Dongzhi Zhang & Yongyuan Zhang & Zhenxin Zhu & Shuo Wu & Yanxun Liu & Fang Tang & Xiaowei Yang & Fuzhong Xue, 2012. "Association between Leukocyte and Metabolic Syndrome in Urban Han Chinese: A Longitudinal Cohort Study," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-7, November.
    • Handle: RePEc:plo:pone00:0049875
    DOI: 10.1371/journal.pone.0049875
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