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CCL18 in a Multiplex Urine-Based Assay for the Detection of Bladder Cancer

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  • Virginia Urquidi
  • Jeongsoon Kim
  • Myron Chang
  • Yunfeng Dai
  • Charles J Rosser
  • Steve Goodison

Abstract

The early detection of bladder cancer (BCa) is pivotal for successful patient treatment and management. Through genomic and proteomic studies, we have identified a number of bladder cancer-associated biomarkers that have potential clinical utility. In a case-control study, we examined voided urines from 127 subjects: 64 tumor-bearing subjects and 63 controls. The urine concentrations of the following proteins were assessed by enzyme-linked immunosorbent assay (ELISA); C-C motif chemokine 18 (CCL18), Plasminogen Activator Inhibitor 1 (PAI-1) and CD44. Data were compared to a commercial ELISA-based BCa detection assay (BTA-Trak©) and voided urinary cytology. We used analysis of the area under the curve of receiver operating characteristic curves to compare the ability of CCL18, PAI-1, CD44, and BTA to detect BCa in voided urine samples. Urinary concentrations of CCL18, PAI-1, and BTA were significantly elevated in subjects with BCa. CCL18 was the most accurate biomarker (AUC; 0.919; 95% confidence interval [CI], 0.8704-0.9674). Multivariate regression analysis highlighted CCL18 (OR; 18.31; 95% CI, 4.95-67.70, p

Suggested Citation

  • Virginia Urquidi & Jeongsoon Kim & Myron Chang & Yunfeng Dai & Charles J Rosser & Steve Goodison, 2012. "CCL18 in a Multiplex Urine-Based Assay for the Detection of Bladder Cancer," PLOS ONE, Public Library of Science, vol. 7(5), pages 1-7, May.
    • Handle: RePEc:plo:pone00:0037797
    DOI: 10.1371/journal.pone.0037797
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