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Profiles of Multidrug Resistance Protein-1 in the Peripheral Blood Mononuclear Cells of Patients with Refractory Epilepsy

Author

Listed:
  • Jae-Jun Ban
  • Keun-Hwa Jung
  • Kon Chu
  • Soon-Tae Lee
  • Daejong Jeon
  • Kyung-Il Park
  • Hye-Jin Moon
  • Hyeyun Kim
  • Sunghun Kim
  • Sang Kun Lee
  • Jae-Kyu Roh

Abstract

Background: About one third of patients with epilepsy become refractory to therapy despite receiving adequate medical treatment, possibly from multidrug resistance. P-glycoprotein, encoded by multidrug resistance protein-1 (MDR1) gene, at the blood brain barrier is considered as a major factor mediating drug efflux and contributing to resistance. Given that peripheral blood mononuclear cells (PBMNCs) express MDR1, we investigated a MDR1 status of PBMNCs in various subsets of epilepsy patients and demonstrated their association with clinical characteristics. Methodology/Principal Findings: Clinical and MDR1 data were collected from 140 patients with epilepsy, 30 healthy volunteers, and 20 control patients taking anti-epileptic drugs. PBMNCs were isolated, and basal MDR1 levels and MDR1 conformational change levels were measured by flow cytometry. MDR1 profiles were analyzed according to various clinical parameters, including seizure frequency and number of medications used in epilepsy patients. Epilepsy patients had a higher basal MDR1 level than non-epilepsy groups (p

Suggested Citation

  • Jae-Jun Ban & Keun-Hwa Jung & Kon Chu & Soon-Tae Lee & Daejong Jeon & Kyung-Il Park & Hye-Jin Moon & Hyeyun Kim & Sunghun Kim & Sang Kun Lee & Jae-Kyu Roh, 2012. "Profiles of Multidrug Resistance Protein-1 in the Peripheral Blood Mononuclear Cells of Patients with Refractory Epilepsy," PLOS ONE, Public Library of Science, vol. 7(5), pages 1-6, May.
    • Handle: RePEc:plo:pone00:0036985
    DOI: 10.1371/journal.pone.0036985
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