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A Microalbuminuria Threshold to Predict the Risk for the Development of Diabetic Retinopathy in Type 2 Diabetes Mellitus Patients

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Listed:
  • Haibing Chen
  • Zhi Zheng
  • Yan Huang
  • Kaifeng Guo
  • Junxi Lu
  • Lei Zhang
  • Haoyong Yu
  • Yuqian Bao
  • Weiping Jia

Abstract

Objective: To test the hypothesis that a microalbuminuria (MA) threshold can help predict the risk for the development of diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM)_ patients. Design: We conducted a cross-sectional study of 4739 subjects with T2DM and a prospective study of 297 subjects with T2DM in China respectively. Methods: Clinical and laboratory data were collected and biologic risk factors associated with any DR were analysed. Results: In the cross-sectional study, we found that MA was an independent risk factor for DR development; further, when the patients were divided into MA deciles, odds ratio (ORs) of DR for the patients in the sixth MA decile (10.7 mg/24 h) was 1.579-fold (1.161–2.147) compared to that for patients in the first MA decile. Furthermore, the OR of DR increased with a gradual increase in MA levels. Similarly, in the prospective study, during a mean follow-up of 4.5 years, we found that 51 patients (29.0%) of the 176 subjects with high MA level (10.7–30 mg/24 h) developed DR, while 17 patients (14.1%) of the 121 subjects with lower MA (

Suggested Citation

  • Haibing Chen & Zhi Zheng & Yan Huang & Kaifeng Guo & Junxi Lu & Lei Zhang & Haoyong Yu & Yuqian Bao & Weiping Jia, 2012. "A Microalbuminuria Threshold to Predict the Risk for the Development of Diabetic Retinopathy in Type 2 Diabetes Mellitus Patients," PLOS ONE, Public Library of Science, vol. 7(5), pages 1-6, May.
    • Handle: RePEc:plo:pone00:0036718
    DOI: 10.1371/journal.pone.0036718
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