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Young HIV-Infected Children and Their Adult Caregivers Prefer Tablets to Syrup Antiretroviral Medications in Africa

Author

Listed:
  • Patricia Nahirya-Ntege
  • Adrian Cook
  • Tichaona Vhembo
  • Wilfred Opilo
  • Rachel Namuddu
  • Richard Katuramu
  • Jessica Tezikyabbiri
  • Bethany Naidoo-James
  • Diana Gibb
  • on behalf of the ARROW Trial Team

Abstract

Background: Provision of anti-retroviral therapy (ART) for HIV-infected children is complicated using syrup formulations, which are costlier than tablets, harder to transport and store and difficult for health-workers to prescribe and caregivers to administer. Dispersible/crushable tablets may be more appropriate. We studied the acceptability of syrups and scored tablets among young children who used both in the AntiRetroviral Research fOr Watoto (ARROW) trial. Methods: ARROW is an ongoing randomized trial of paediatric ART monitoring and treatment strategies in 1206 children in Uganda and Zimbabwe. 405 children initially received syrups of combination ART including Nevirapine, Zidovudine, Abacavir and Lamivudine before changing, when reaching the 12-

Suggested Citation

  • Patricia Nahirya-Ntege & Adrian Cook & Tichaona Vhembo & Wilfred Opilo & Rachel Namuddu & Richard Katuramu & Jessica Tezikyabbiri & Bethany Naidoo-James & Diana Gibb & on behalf of the ARROW Trial Tea, 2012. "Young HIV-Infected Children and Their Adult Caregivers Prefer Tablets to Syrup Antiretroviral Medications in Africa," PLOS ONE, Public Library of Science, vol. 7(5), pages 1-8, May.
    • Handle: RePEc:plo:pone00:0036186
    DOI: 10.1371/journal.pone.0036186
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