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Sequencing by Hybridization of Long Targets

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  • Yu Qin
  • Tobias M Schneider
  • Michael P Brenner

Abstract

Sequencing by Hybridization (SBH) reconstructs an n-long target DNA sequence from its biochemically determined l-long subsequences. In the standard approach, the length of a uniformly random sequence that can be unambiguously reconstructed is limited to due to repetitive subsequences causing reconstruction degeneracies. We present a modified sequencing method that overcomes this limitation without the need for different types of biochemical assays and is robust to error.

Suggested Citation

  • Yu Qin & Tobias M Schneider & Michael P Brenner, 2012. "Sequencing by Hybridization of Long Targets," PLOS ONE, Public Library of Science, vol. 7(5), pages 1-6, May.
    • Handle: RePEc:plo:pone00:0035819
    DOI: 10.1371/journal.pone.0035819
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