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Tuberculosis in HIV-Negative and HIV-Infected Patients in a Low-Incidence Country: Clinical Characteristics and Treatment Outcomes

Author

Listed:
  • Lukas Fenner
  • Sebastien Gagneux
  • Jean-Paul Janssens
  • Jan Fehr
  • Matthias Cavassini
  • Matthias Hoffmann
  • Enos Bernasconi
  • Jacques Schrenzel
  • Thomas Bodmer
  • Erik C Böttger
  • Peter Helbling
  • Matthias Egger
  • for the Swiss HIV Cohort and Molecular Epidemiology of Tuberculosis Study Groups

Abstract

Background: In Switzerland and other developed countries, the number of tuberculosis (TB) cases has been decreasing for decades, but HIV-infected patients and migrants remain risk groups. The aim of this study was to compare characteristics of TB in HIV-negative and HIV-infected patients diagnosed in Switzerland, and between coinfected patients enrolled and not enrolled in the national Swiss HIV Cohort Study (SHCS). Methods and Findings: All patients diagnosed with culture-confirmed TB in the SHCS and a random sample of culture-confirmed cases reported to the national TB registry 2000–2008 were included. Outcomes were assessed in HIV-infected patients and considered successful in case of cure or treatment completion. Ninety-three SHCS patients and 288 patients selected randomly from 4221 registered patients were analyzed. The registry sample included 10 (3.5%) coinfected patients not enrolled in the SHCS: the estimated number of HIV-infected patients not enrolled in the SHCS but reported to the registry 2000–2008 was 146 (95% CI 122–173). Coinfected patients were more likely to be from sub-Saharan Africa (51.5% versus 15.8%, P

Suggested Citation

  • Lukas Fenner & Sebastien Gagneux & Jean-Paul Janssens & Jan Fehr & Matthias Cavassini & Matthias Hoffmann & Enos Bernasconi & Jacques Schrenzel & Thomas Bodmer & Erik C Böttger & Peter Helbling & Matt, 2012. "Tuberculosis in HIV-Negative and HIV-Infected Patients in a Low-Incidence Country: Clinical Characteristics and Treatment Outcomes," PLOS ONE, Public Library of Science, vol. 7(3), pages 1-5, March.
    • Handle: RePEc:plo:pone00:0034186
    DOI: 10.1371/journal.pone.0034186
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