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Asymmetrical Dimethylarginine - More Sensitive than NT-proBNP to Diagnose Heart Failure in Adults with Congenital Heart Disease

Author

Listed:
  • Oktay Tutarel
  • Agnieszka Denecke
  • Stefanie M Bode-Böger
  • Jens Martens-Lobenhoffer
  • Svjetlana Lovric
  • Johann Bauersachs
  • Bernhard Schieffer
  • Mechthild Westhoff-Bleck
  • Jan T Kielstein

Abstract

Background: Chronic heart failure is an important cause for morbidity and mortality in adults with congenital heart disease (ACHD). While NT-proBNP is an established biomarker for heart failure of non-congenital origin, its value in ACHD has limitations. Asymmetrical dimethylarginine (ADMA) correlates with disease severity and independently predicts adverse clinical events in heart failure of non-congenital origin. Its role in ACHD has not been investigated. Methods: In 102 patients ADMA and NT-proBNP were measured and related to NYHA class, systemic ventricular function and parameters of cardiopulmonary exercise testing. Results: In contrast to NT-proBNP ADMA differentiated between NYHA classes I-III. Both, ADMA and NT-proBNP showed a good correlation with parameters of cardiopulmonary exercise testing with comparable receiver-operating characteristic curves for identifying patients with severely limited cardiopulmonary exercise capacity. Conclusion: ADMA seems to be a better biomarker than NT-proBNP for the assessment of NYHA class and as a good as NT-proBNP for the estimation of maximum exercise capacity in adults with congenital heart disease. Its use in clinical routine should be evaluated.

Suggested Citation

  • Oktay Tutarel & Agnieszka Denecke & Stefanie M Bode-Böger & Jens Martens-Lobenhoffer & Svjetlana Lovric & Johann Bauersachs & Bernhard Schieffer & Mechthild Westhoff-Bleck & Jan T Kielstein, 2012. "Asymmetrical Dimethylarginine - More Sensitive than NT-proBNP to Diagnose Heart Failure in Adults with Congenital Heart Disease," PLOS ONE, Public Library of Science, vol. 7(3), pages 1-6, March.
    • Handle: RePEc:plo:pone00:0033795
    DOI: 10.1371/journal.pone.0033795
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