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Amerind Ancestry, Socioeconomic Status and the Genetics of Type 2 Diabetes in a Colombian Population

Author

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  • Desmond D Campbell
  • Maria V Parra
  • Constanza Duque
  • Natalia Gallego
  • Liliana Franco
  • Arti Tandon
  • Tábita Hünemeier
  • Cátira Bortolini
  • Alberto Villegas
  • Gabriel Bedoya
  • Mark I McCarthy
  • Alkes Price
  • David Reich
  • Andrés Ruiz-Linares

Abstract

The “thrifty genotype” hypothesis proposes that the high prevalence of type 2 diabetes (T2D) in Native Americans and admixed Latin Americans has a genetic basis and reflects an evolutionary adaptation to a past low calorie/high exercise lifestyle. However, identification of the gene variants underpinning this hypothesis remains elusive. Here we assessed the role of Native American ancestry, socioeconomic status (SES) and 21 candidate gene loci in susceptibility to T2D in a sample of 876 T2D cases and 399 controls from Antioquia (Colombia). Although mean Native American ancestry is significantly higher in T2D cases than in controls (32% v 29%), this difference is confounded by the correlation of ancestry with SES, which is a stronger predictor of disease status. Nominally significant association (P 1 was observed for markers selected from previous T2D genome-wide association studies, consistent with a role for Old World variants in susceptibility to T2D in Latin Americans. No association was found to the only known Native American-specific gene variant previously associated with T2D in a Mexican sample (rs9282541 in ABCA1). An admixture mapping scan with 1,536 ancestry informative markers (AIMs) did not identify genome regions with significant deviation of ancestry in Antioquia. Exclusion analysis indicates that this scan rules out ∼95% of the genome as harboring loci with ancestry risk ratios >1.22 (at P

Suggested Citation

  • Desmond D Campbell & Maria V Parra & Constanza Duque & Natalia Gallego & Liliana Franco & Arti Tandon & Tábita Hünemeier & Cátira Bortolini & Alberto Villegas & Gabriel Bedoya & Mark I McCarthy & Alke, 2012. "Amerind Ancestry, Socioeconomic Status and the Genetics of Type 2 Diabetes in a Colombian Population," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-7, April.
    • Handle: RePEc:plo:pone00:0033570
    DOI: 10.1371/journal.pone.0033570
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    References listed on IDEAS

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    1. Jared Diamond, 2003. "The double puzzle of diabetes," Nature, Nature, vol. 423(6940), pages 599-602, June.
    2. David De Ferranti & Guillermo E. Perry & Francisco H.G. Ferreira & Michael Walton, 2004. "Inequality in Latin America : Breaking with History?," World Bank Publications - Books, The World Bank Group, number 15009, December.
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    Cited by:

    1. Qiman Sun & Kang Song & Xizhong Shen & Yu Cai, 2012. "The Association between KCNQ1 Gene Polymorphism and Type 2 Diabetes Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-9, November.
    2. Latife Pereira & Roxana Zamudio & Giordano Soares-Souza & Phabiola Herrera & Lilia Cabrera & Catherine C Hooper & Jaime Cok & Juan M Combe & Gloria Vargas & William A Prado & Silvana Schneider & Ferna, 2012. "Socioeconomic and Nutritional Factors Account for the Association of Gastric Cancer with Amerindian Ancestry in a Latin American Admixed Population," PLOS ONE, Public Library of Science, vol. 7(8), pages 1-8, August.

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