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Distinguishing Type 2 Diabetes from Type 1 Diabetes in African American and Hispanic American Pediatric Patients

Author

Listed:
  • Nancy Keller
  • Suruchi Bhatia
  • Jeanah N Braden
  • Ginny Gildengorin
  • Jameel Johnson
  • Rachel Yedlin
  • Teresa Tseng
  • Jacquelyn Knapp
  • Nicole Glaser
  • Paula Jossan
  • Shawn Teran
  • Erinn T Rhodes
  • Janelle A Noble

Abstract

Objective: To test the hypothesis that clinical observations made at patient presentation can distinguish type 2 diabetes (T2D) from type 1 diabetes (T1D) in pediatric patients aged 2 to 18. Subjects and Methods: Medical records of 227 African American and 112 Hispanic American pediatric patients diagnosed as T1D or T2D were examined to compare parameters in the two diseases. Age at presentation, BMI z-score, and gender were the variables used in logistic regression analysis to create models for T2D prediction. Results: The regression-based model created from African American data had a sensitivity of 92% and a specificity of 89%; testing of a replication cohort showed 91% sensitivity and 93% specificity. A model based on the Hispanic American data showed 92% sensitivity and 90% specificity. Similarities between African American and Hispanic American patients include: (1) age at onset for both T1D and T2D decreased from the 1980s to the 2000s; (2) risk of T2D increased markedly with obesity. Racial/ethnic-specific observations included: (1) in African American patients, the proportion of females was significantly higher than that of males for T2D compared to T1D (p

Suggested Citation

  • Nancy Keller & Suruchi Bhatia & Jeanah N Braden & Ginny Gildengorin & Jameel Johnson & Rachel Yedlin & Teresa Tseng & Jacquelyn Knapp & Nicole Glaser & Paula Jossan & Shawn Teran & Erinn T Rhodes & Ja, 2012. "Distinguishing Type 2 Diabetes from Type 1 Diabetes in African American and Hispanic American Pediatric Patients," PLOS ONE, Public Library of Science, vol. 7(3), pages 1-7, March.
    • Handle: RePEc:plo:pone00:0032773
    DOI: 10.1371/journal.pone.0032773
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