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Estimation of the Health Impact and Cost-Effectiveness of Influenza Vaccination with Enhanced Effectiveness in Canada

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  • David N Fisman
  • Ashleigh R Tuite

Abstract

Introduction: The propensity for influenza viruses to mutate and recombine makes them both a familiar threat and a prototype emerging infectious disease. Emerging evidence suggests that the use of MF59-adjuvanted vaccines in older adults and young children enhances protection against influenza infection and reduces adverse influenza-attributable outcomes compared to unadjuvanted vaccines. The health and economic impact of such vaccines in the Canadian population are uncertain. Methods: We constructed an age-structured compartmental model simulating the transmission of influenza in the Canadian population over a ten-year period. We compared projected health outcomes (quality-adjusted life years (QALY) lost), costs, and incremental cost-effectiveness ratios (ICERs) for three strategies: (i) current use of unadjuvanted trivalent influenza vaccine; (ii) use of MF59-adjuvanted influenza vaccine adults ≥65 in the Canadian population, and (iii) adjuvanted vaccine used in both older adults and children aged

Suggested Citation

  • David N Fisman & Ashleigh R Tuite, 2011. "Estimation of the Health Impact and Cost-Effectiveness of Influenza Vaccination with Enhanced Effectiveness in Canada," PLOS ONE, Public Library of Science, vol. 6(11), pages 1-9, November.
    • Handle: RePEc:plo:pone00:0027420
    DOI: 10.1371/journal.pone.0027420
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    References listed on IDEAS

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    1. Beate Sander & Jeffrey C Kwong & Chris T Bauch & Andreas Maetzel & Allison McGeer & Janet M Raboud & Murray Krahn, 2010. "Economic Appraisal of Ontario's Universal Influenza Immunization Program: A Cost-Utility Analysis," PLOS Medicine, Public Library of Science, vol. 7(4), pages 1-11, April.
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    Cited by:

    1. Gerhart Knerer & Christine S M Currie & Sally C Brailsford, 2020. "The economic impact and cost-effectiveness of combined vector-control and dengue vaccination strategies in Thailand: results from a dynamic transmission model," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 14(10), pages 1-32, October.
    2. Jae-Won Yun & Min Joo Choi & Gyeong-Seon Shin & Jae-Ok Lim & Ji Yun Noh & Yun-Kyung Kim & Joon Young Song & Woo Joo Kim & Sang-Eun Choi & Hee Jin Cheong, 2019. "Cost-effectiveness of influenza vaccine strategies for the elderly in South Korea," PLOS ONE, Public Library of Science, vol. 14(1), pages 1-20, January.

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