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The Effect of Tuberculosis on Mortality in HIV Positive People: A Meta-Analysis

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  • Masja Straetemans
  • Ana L Bierrenbach
  • Nico Nagelkerke
  • Philippe Glaziou
  • Marieke J van der Werf

Abstract

Background: Tuberculosis is a leading cause of death in people living with HIV (PLWH). We conducted a meta analysis to assess the effect of tuberculosis on mortality in people living with HIV. Methods: Meta-analysis of cohort studies assessing the effect of tuberculosis on mortality in PLWH. To identify eligible studies we systematically searched electronic databases (until December 2008), performed manual searches of citations from relevant articles, and reviewed conference proceedings. Multivariate hazard ratios (HR) of mortality in PLWH with and without tuberculosis, estimated in individual cohort studies, were pooled using random effect weighting according to “Der Simonian Laird method” if the p-value of the heterogeneity test was

Suggested Citation

  • Masja Straetemans & Ana L Bierrenbach & Nico Nagelkerke & Philippe Glaziou & Marieke J van der Werf, 2010. "The Effect of Tuberculosis on Mortality in HIV Positive People: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 5(12), pages 1-10, December.
    • Handle: RePEc:plo:pone00:0015241
    DOI: 10.1371/journal.pone.0015241
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    Cited by:

    1. Heidi M Soeters & Charles Poole & Monita R Patel & Annelies Van Rie, 2013. "The Effect of Tuberculosis Treatment at Combination Antiretroviral Therapy Initiation on Subsequent Mortality: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-1, October.
    2. Eline L Korenromp & Philippe Glaziou & Christopher Fitzpatrick & Katherine Floyd & Mehran Hosseini & Mario Raviglione & Rifat Atun & Brian Williams, 2012. "Implementing the Global Plan to Stop TB, 2011–2015 – Optimizing Allocations and the Global Fund’s Contribution: A Scenario Projections Study," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-10, June.
    3. Masja Straetemans & Philippe Glaziou & Ana L Bierrenbach & Charalambos Sismanidis & Marieke J van der Werf, 2011. "Assessing Tuberculosis Case Fatality Ratio: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 6(6), pages 1-1, June.

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