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JULIDE: A Software Tool for 3D Reconstruction and Statistical Analysis of Autoradiographic Mouse Brain Sections

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  • Delphine Ribes
  • Julia Parafita
  • Rémi Charrier
  • Fulvio Magara
  • Pierre J Magistretti
  • Jean-Philippe Thiran

Abstract

In this article we introduce JULIDE, a software toolkit developed to perform the 3D reconstruction, intensity normalization, volume standardization by 3D image registration and voxel-wise statistical analysis of autoradiographs of mouse brain sections. This software tool has been developed in the open-source ITK software framework and is freely available under a GPL license. The article presents the complete image processing chain from raw data acquisition to 3D statistical group analysis. Results of the group comparison in the context of a study on spatial learning are shown as an illustration of the data that can be obtained with this tool.

Suggested Citation

  • Delphine Ribes & Julia Parafita & Rémi Charrier & Fulvio Magara & Pierre J Magistretti & Jean-Philippe Thiran, 2010. "JULIDE: A Software Tool for 3D Reconstruction and Statistical Analysis of Autoradiographic Mouse Brain Sections," PLOS ONE, Public Library of Science, vol. 5(11), pages 1-8, November.
    • Handle: RePEc:plo:pone00:0014094
    DOI: 10.1371/journal.pone.0014094
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