IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0013057.html
   My bibliography  Save this article

Alpha-Adducin Gly460Trp Polymorphism and Hypertension Risk: A Meta-Analysis of 22 Studies Including 14303 Cases and 15961 Controls

Author

Listed:
  • Kuo Liu
  • Jielin Liu
  • Yan Huang
  • Ya Liu
  • Yuqing Lou
  • Zuoguang Wang
  • Hong Zhang
  • Shan Yan
  • Zhizhong Li
  • Shaojun Wen

Abstract

Background: No clear consensus has been reached on the alpha-adducin polymorphism (Gly460Trp) and essential hypertension risk. We performed a meta-analysis in an effort to systematically summarize the possible association. Methodology/Principal Findings: Studies were identified by searching MEDLINE and EMBASE databases complemented with perusal of bibliographies of retrieved articles and correspondence with original authors. The fixed-effects model and the random-effects model were applied for dichotomous outcomes to combine the results of the individual studies. We selected 22 studies that met the inclusion criteria including a total of 14303 hypertensive patients and 15961 normotensive controls. Overall, the 460Trp allele showed no statistically significant association with hypertension risk compared to Gly460 allele (P = 0.69, OR = 1.02, 95% CI 0.94–1.10, Pheterogeneity

Suggested Citation

  • Kuo Liu & Jielin Liu & Yan Huang & Ya Liu & Yuqing Lou & Zuoguang Wang & Hong Zhang & Shan Yan & Zhizhong Li & Shaojun Wen, 2010. "Alpha-Adducin Gly460Trp Polymorphism and Hypertension Risk: A Meta-Analysis of 22 Studies Including 14303 Cases and 15961 Controls," PLOS ONE, Public Library of Science, vol. 5(9), pages 1-9, September.
    • Handle: RePEc:plo:pone00:0013057
    DOI: 10.1371/journal.pone.0013057
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013057
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0013057&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0013057?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Beáta Soltész & Péter Pikó & János Sándor & Zsigmond Kósa & Róza Ádány & Szilvia Fiatal, 2020. "The genetic risk for hypertension is lower among the Hungarian Roma population compared to the general population," PLOS ONE, Public Library of Science, vol. 15(6), pages 1-17, June.
    2. Yan-yan Li, 2012. "α-Adducin Gly460Trp Gene Mutation and Essential Hypertension in a Chinese Population: A Meta-Analysis including 10960 Subjects," PLOS ONE, Public Library of Science, vol. 7(1), pages 1-12, January.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0013057. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.