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Routine Laboratory Results and Thirty Day and One-Year Mortality Risk Following Hospitalization with Acute Decompensated Heart Failure

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  • Victor Novack
  • Michael Pencina
  • Doron Zahger
  • Lior Fuchs
  • Roman Nevzorov
  • Allan Jotkowitz
  • Avi Porath

Abstract

Introduction: Several blood tests are performed uniformly in patients hospitalized with acute decompensated heart failure and are predictive of the outcomes: complete blood count, electrolytes, renal function, glucose, albumin and uric acid. We sought to evaluate the relationship between routine admission laboratory tests results, patient characteristics and 30-day and one-year mortality of patients admitted for decompensated heart failure and to construct a simple mortality prediction tool. Methods: A retrospective population based study. Data from seven tertiary hospitals on all admissions with a principal diagnosis of heart failure during the years 2002–2005 throughout Israel were captured. Results: 8,246 patients were included in the study cohort. Thirty day mortality rate was 8.5% (701 patients) and one-year mortality rate was 28.7% (2,365 patients). Addition of five routine laboratory tests results (albumin, sodium, blood urea, uric acid and WBC) to a set of clinical and demographic characteristics improved c-statistics from 0.76 to 0.81 for 30-days and from 0.72 to 0.76 for one-year mortality prediction (both p-values

Suggested Citation

  • Victor Novack & Michael Pencina & Doron Zahger & Lior Fuchs & Roman Nevzorov & Allan Jotkowitz & Avi Porath, 2010. "Routine Laboratory Results and Thirty Day and One-Year Mortality Risk Following Hospitalization with Acute Decompensated Heart Failure," PLOS ONE, Public Library of Science, vol. 5(8), pages 1-11, August.
    • Handle: RePEc:plo:pone00:0012184
    DOI: 10.1371/journal.pone.0012184
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